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Ambient Light Resistant Shortwave Infrared Fluorescence Imaging for Preclinical Tumor Delineation via the pH Low-Insertion Peptide Conjugated to Indocyanine Green

https://doi.org/10.2967/jnumed.123.265686

Mc_Larney, Benedict Edward; Kim, Mijin; Roberts, Sheryl; Skubal, Magdalena; Hsu, Hsiao-Ting; Ogirala, Anuja; Pratt, Edwin C; Pillarsetty, Naga_Vara Kishore; Heller, Daniel A; Lewis, Jason S; et al (October 2023, The Journal of nuclear medicine)

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Sc-HOPO: A Potential Construct for Use in Radioscandium-Based Radiopharmaceuticals

https://doi.org/10.1021/acs.inorgchem.2c03931

Phipps, Michael D.; Cingoranelli, Shelbie; Bhupathiraju, N. V.; Younes, Ali; Cao, Minhua; Sanders, Vanessa A.; Neary, Michelle C.; Devany, Matthew H.; Cutler, Cathy S.; Lopez, Gustavo E.; et al (February 2023, Inorganic Chemistry)

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Comparison of Methods for Surface Modification of Barium Titanate Nanoparticles for Aqueous Dispersibility: Toward Biomedical Utilization of Perovskite Oxides

https://doi.org/10.1021/acsami.0c10063

Huang, Richard H.; Sobol, Nicholas B.; Younes, Ali; Mamun, Tanjeena; Lewis, Jason S.; Ulijn, Rein V.; O’Brien, Stephen (November 2020, ACS Applied Materials & Interfaces)

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Aromatic carbohydrate amphiphile disrupts cancer spheroids and prevents relapse

https://doi.org/10.1039/d0nr05008c

Brito, Alexandra; Pereira, Patrícia M.; Reis, Rui L.; Ulijn, Rein V.; Lewis, Jason S.; Pires, Ricardo A.; Pashkuleva, Iva (October 2020, Nanoscale)

Spheroids recapitulate the organization, heterogeneity and microenvironment of solid tumors. Herein, we targeted spatiotemporally the accelerated metabolism of proliferative cells located on the spheroid surface that ensure structure maintenance and/or growth. We demonstrate that phosphorylated carbohydrate amphiphile acts as a potent antimetabolite due to glycolysis inhibition and to in situ formation of supramolecular net around spheroid surface where alkaline phosphatase is overexpressed. The efficiency of the treatment is higher in spheroids as compared to the conventional 2D cultures because of the 2-fold higher expression of glucose transporter 1 (GLUT1). Moreover, treated spheroids do not undergo following relapse.
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